Endocrine Abstracts

Objective: To study the effect of neurohormones kisspeptin and neurokinin B on the indices of calcium-phosphate and electrolyte metabolism in patients with neuroendocrine pathology.Material and Methods: Eighty-two female patients were included in this pilot study divided into 2 groups: ‘Cushing’s disease’ group (n=51) and ‘Acromegaly’ group (n=31). Median age was 33 years [27; 38] in ‘Cushing’s disease...

Introduction: Hyponatremia after transnasal neurosurgery for pituitary adenomas is a serious and not so rare complication. It often occurs in a delayed manner after patient’s discharge and is a major cause of readmission. The pathogenesis of postneurosurgical hyponatremia is not clear yet.Aims: To study the role of posterior pituitary hormones (antidiuretic hormone (ADH) and apelin) and reaction of renin-aldosterone system (RAS) at hyponatremia mani...

Objective: Tumor-induced osteomalacia is a rare paraneoplastic syndrome in which fibroblast growth factor 23 (FGF-23) hyperproduction by tumor causes renal phosphate wasting, severe hypophosphatemia and osteomalacia. Localization of the tumor can be a major diagnostic challenge.Material and methods: We present a clinical case concerning a 62-year old woman previously diagnosed with hypophosphatemic osteomalacia, with a slight improvement of clinical and ...

Objectives: to study the response of calcium and phosphate homeostasis parameters to the cholecalciferol loading dose in patients with predialysis chronic kidney disease (CKD). Methods: We examined 17 patients with stage 3 CKD (CKD3) and 9 patients with stages 4–5 CKD (CKD4-5) without previously known disorders of mineral metabolism and intake of interfering drugs during last 3 months. The assessments included serum 25-hydroxyvitamin D (25(OH)D), free 25...